Osteons are cylindrical structures of bone created by matrix resorbing osteoclasts, followed by osteoblasts that deposit new bone. Osteons align with the principal loading direction and it is thought that the osteoclasts are directed by osteocytes, the mechanosensitive cells that reside inside the bone matrix. These osteocytes are presumably controlled by interstitial fluid flow, induced by the physiological loading of bones. Here I consider the stimulation of osteocytes while the osteon is closed by osteoblasts. In a conceptual finite element model, (...) bone is considered a poro‐elastic material and subjected to locomotion‐induced loading conditions. It appears that the magnitude of flow is constant along the closing cone, while shear strain rate in the bone matrix diminishes linearly with the deposition of bone. This suggests that shear strain rate, rather than fluid flow, is the physical cue that controls osteocytes and bone deposition in newly formed osteons. (shrink)

As Anthony Tol explains in his general introduction to (his translation of) Vollenhoven's 1926 inaugural address, the Reformed epistemology that Vollenhoven espouses here is essentially three-layered. Most basic is the intuition - the starting point of all knowing. It starts with discerning. Then there is knowledge. At this point language, communication, and judgments are relevant. The third layer is thought. Thought may disclose and renew or criticize and correct against the background of what we know. Thought is also central to (...) concept formation. The factor that runs through these three layers is truth, taken realistically. It has its seat in the intuition of discerning. It is central to knowledge, for the essence of knowledge is said to be "possessing truth." And in connection with thought, or more particularly in concept formation, the latter is described as "truth grasped in a form." Apart from advocating his own understanding of epistemology in this inaugural address, Vollenhoven takes issue with how epistemology is generally understood. The critique is cast in a historical overview. (shrink)

1. bd. Inleiding en geschiedenis der Grieksche wijsbegeerte vóór Platoon en Aristoteles.

AimThe neurocognitive basis of Developmental Coordination Disorder remains an issue of continued debate. This combined systematic review and meta-analysis provides a synthesis of recent experimental studies on the motor control, cognitive, and neural underpinnings of DCD.MethodsThe review included all published work conducted since September 2016 and up to April 2021. One-hundred papers with a DCD-Control comparison were included, with 1,374 effect sizes entered into a multi-level meta-analysis.ResultsThe most profound deficits were shown in: voluntary gaze control during movement; cognitive-motor integration; practice-/context-dependent (...) motor learning; internal modeling; more variable movement kinematics/kinetics; larger safety margins when locomoting, and atypical neural structure and function across sensori-motor and prefrontal regions.InterpretationTaken together, these results on DCD suggest fundamental deficits in visual-motor mapping and cognitive-motor integration, and abnormal maturation of motor networks, but also areas of pragmatic compensation for motor control deficits. Implications for current theory, future research, and evidence-based practice are discussed.Systematic Review RegistrationPROSPERO, identifier: CRD42020185444. (shrink)

Van der Merwe, P.J. - Brown, S. 1994. The nearest in affection: Towards a Christian understanding of Islam. (Bladsy 254-255)Van der Merwe, P.J. - Newbigin, L. 1991. The gospel in a pluralist society. (Bladsy 255-256)Van der Merwe, P.J. - Van der Merwe, D.C.S. 'n Watermodel vir die kosmologie of God se twee boeke met spesiale verwysing na Gen 1:1-19 en die moderne kosmologie. (Bladsy 256-258)Van der Merwe, P.J. - Kritzinger, J.J. Saayman, W. On being witnesses. (Bladsy 258-259)Dreyer, T.F.J. - Pieterse, (...) Hennie. Praktiese Teologie as kommunikatiewe handelingsteorie. (Bladsy 260-261)Boshoff, F.J. - Burger, C.W., Müller, B.A. Smit D.J. Riglyne vir prediking oor die Pastorale en Algemene Briewe (Woord teen die lig 11/6). (Bladsy 261-262)Du Toit, B.A. - Van Aarde, Andries. Kultuurhistoriese agtergrond van die Nuwe Testament: Die eerste-eeuse Mediterreense sosiale konteks. (Bladsy 263-264)Van der Merwe, Paul - Van der Westhuizen, H.G. Herder van Angola. (Bladsy 264-268)Beukes J.A. - Burger, C.W., Müller, B.A. Smit D.J. Riglyne vir prediking oor regverdiging en reg: Woord teen die lig 111/3. (Bladsy 260-270)Engelbrecht Johannes J. - Joubert, Stephan. Matteus vandag. (Bladsy 270-272)Botes H.J. - Celliers, Johan. God vir ons. (Bladsy 272-274)Pretorius, S.P. - Papp, Kálmán. Die Nederduitsch Hervormde Gemeente Krugersdorp 1891 - 1991. (Bladsy 274-275). (shrink)

Originally published in 1936, this book presents the ancient Greek text of the paraphrases and quotations of Zeno's philosophical arguments, together with a facing-page English translation and editorial commentary. Detailed notes are incorporated throughout and a bibliography is also included. This book will be of value to anyone with an interest in Zeno and ancient philosophy.

Commentators are divided on the interpretation of Metaphysics Z4 1029b13–22. For one thing, it is unclear whether the passage rejects a claim about the essence of surface, or about the essence of pale. It is usually thought that the claim is disavowed because it involves a circular definition. However, this is conjectural, since Aristotle does not explicitly say anything about circularity in the lines in question. I argue here for an alternative account, which reads the disputed lines as an extension (...) of the immediately preceding remarks. If correct, this also solves the problem as to just what Aristotle is denying. As will emerge, my story is helped by St. Thomas’ reading of lines 21–22, an account that has been curiously ignored in the recent literature. (shrink)